Red River Pharma - Production

Production

The Dispensing, Milling, and Blending departments at Red River Pharma are the first stages of production at our facility. The dispensary area is where all the raw materials, active and inactive, are precisely calculated and measured into lined containers for each production batch. Each ingredient is weighed and recorded into our production batch records.

Milling Video

Our dispensary also contains a Milling area where all raw ingredients undergo a screening process. There are two separate machines we currently use at this stage, which are a comil and a Vorti Siv 30 inch sieve. The total capacity of the comil is 200-2000 KG per hour and 1500 KG per hour for our 30 inch sieve. All products are screened directly into a Bulk container.

Blending Video

Our Blending stage is necessary to obtain a uniform mixture of the various ingredients. Each Bulk container is transferred directly from our milling area to our Blending area. The bulk container is loaded directly into our Matcon IBC Blender and rotated at the speed and for the duration as specified in the product batch record.

The compression/encapsulation departments at Red River Pharma transforms the active ingredients that go into our innovative products into tablet or capsule form.

Compression Video

We have three presses, each capable of producing one million tablets per day. Our newest press is the Sejong MRC-30N which features "D" type tooling capable of exerting ten metric tons of pressure on each tablet station. Operators follow detailed SOP's and record all testing in batch records which keep track of each product produced.

The combination of state of the art equipment, robust quality systems, in-process testing and more than 15 years of compression knowledge ensure consistency and quality.

The coating department is vital to many aspects of the final product, adding pharmaceutical elegance, identity, aiding in swallowing and preventing degradation of the active ingredients.

Coating Video

The O'Hara FC 48" is capable of coating 2 million tablets per day. In-process testing occurs throughout the coating process, some of which are captured by the coater control system.

High quality, great looking tablets are the result of attention to detail, a sound manufacturing process that is strictly and consistently followed, and technical knowledge.

Currently we have one line for bottles.

Packaging Video

Bottle Line consist of many pieces of equipment integrated into one line. Our line is capable of running multiple bottle and cap sizes along with multiple tablet, caplet and gelcap sizes.

The tablet counter utilizes channel feeding technology which gives us a broad range of tablets that can be ran with out change parts and with a fill accuracy of 100%.

This bottle line is design to run 50 bottles/min and requires limited change parts for changing bottle sizes or products which requires less time for changeovers and increases production time.

Integrated inspection system confirms correct labeling and information is applied to each bottle.

Case Studies

FDA Inspections and Compliance: "We envision compliance enforcement as the next big wave of change
Within food, Drug and Dietary Supplement manufacturing."

- Charlie Wiggins, CEO, Red River Pharma

Our plant has been inspected by the FDA. We've had no 483 observations and are completely 111 CFR, 210 CFR and 211 CFR compliant. We also operate with full e-pedigree capabilities. Red River Pharma hasn't waited to correct problems – we've invested our time and resources to be successfully positioned out in fornt of regulatory change. Several companies have contacted us simply because their traditional manufacturing sources have fallen behind the new era of regulatory enforcement. This will be a competitive advantage for the next decade.
Solving the Mystery of a “New” Ingredient: "When Cerefolin wanted to add N-acetylcysteine (NAC), we faced one tremendous challenge – no one knew how it would react with L-methylfolate."

- Dale Scotten, VP, Red River Pharma

A proprietary ingredient can present a wildcard challenge when considering new formulations. NAC itself was a challeneg as a large, coarse (like sugar) active that needed significant compression. Further, we faced a sulphur component that could create an odor risk. Finally, we needed to understand and master the risk of interaction degradation between the actives. We were able to achieve the proper rate of disintegration while masking the odor properties and achieving a very stable final product. The client was thrilled and the product has become the sales leader in their brand family.
New Product Development: "We've delivered new products to market ahead of schedule regardless of the active ingredient profile."

- Dale Scotten, VP, Red River Pharma

New products always carry a degree of uncertainty...and a desire to accelerate the launch schedule. We work with a lean staff that maintains a keen focus to compress working timelines. In many cases, we've completed the process in half the normal market expectation. (i.e. 6 months rather than a full year from concept to market launch). In this way, our competitive advantage can become your competitive advantage.
Methods Development: “The making of a quality tablet is a true art form, and multiple actives present unique challenges. Not everything is compressible.”

- Charlie Wiggins, CEO, Red River Pharma

Testing for multiple "actives" is always difficult. Perhaps no example is more complicated than a prenatal vitamin with more than a dozen active ingredients and another dozen inactive ingredients. Recently RRP was asked to incorporate new (previously unused, untested) proprietary ingredients to an established prenatal formula. The result was not only success during bench analysis – the product has also become a national leader in market sales.

National Leadership in Medical Food Development and Manufacturing